1512psafety of Denosumab (dmab) in Patients (pts) with Stage 4 or Stage 5d Chronic Kidney Disease (ckd).
نویسندگان
چکیده
Aim: DMAB is a human monoclonal antibody that binds to RANK ligand to inhibit osteoclast-mediated resorption and is approved to prevent skeletal-related events in pts with bone metastases from solid tumors. DMAB-induced inhibition of bone resorption may impact calcium (Ca) homeostasis, affecting serum Ca levels. This study evaluated the incidence of hypocalcemia and safety parameters of pts with stage 4 or 5D CKD who were administered two subcutaneous (SC) doses of DMAB.
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متن کاملLactulose efficacy in reduction of nitrogen products,blood potassium and fluid overload in patients with end-stage renal failure ..
Introduction.Chronic kidney disease (CKD) is a major public health problem that often goes unrecognized until late-stage disease.Patients with chronic kidney disease face with uremic toxins and hyperkalemia. Also fluid overload in CKD patients is associated with rapid decline in kidney function.Lactulose is a hyper osmotic agent and as a prebioticplays an important role in regulating serum urea...
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عنوان ژورنال:
- Annals of oncology : official journal of the European Society for Medical Oncology
دوره 25 suppl_4 شماره
صفحات -
تاریخ انتشار 2014